Beilstein J. Org. Chem.2015,11, 1886–1892, doi:10.3762/bjoc.11.203
. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach.
Keywords: fluorescence; microplate
screening; ring closing metathesis; Introduction
Since its discovery in the 1950s, olefin metathesis has developed into one of the most powerful catalytic reactions both in research as well as in industrial applications [1][2][3]. This is mostly due to its excellent chemoselectivity, tolerance of many
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Graphical Abstract
Figure 1:
Catalysts 1–4 tested for the metathesis of profluorescent substrates.